Immunotherapy of Melanoma by Anand Rotte & Madhuri Bhandaru

Author:Anand Rotte & Madhuri Bhandaru
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Accumulation of MDSCs

Tumor cells stimulate the infiltration of tumor tissue with MDSCs that suppress T-cell activity in tumor milieu

Increased MDSC count: melanoma, multiple myeloma and prostate cancer

MDSCs count: inversely associated with response to ipilimumab, adoptive cell transfer and high dose IL-2 treatment

Accumulation of TAMs

Differentiation of TAMs from monocytes is induced by tumor cells

TAM infiltration: melanoma, prostate adenocarcinoma, oral squamous cell carcinomas, glioblastoma, breast cancer, pancreatic cancer and gastric cancer

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